81377  München christian.haass(at)dzne.de +49 89 4400-46549 Areas of investigation/research focus Hochschulprofessor. Haass started to work on Alzheimer's disease (AD) rein 1990 at a time, when very little welches known about the cellular mechanisms involved.  Based on the pathology, which shows invariably the accumulation and deposition of Amyloid ß-peptide (Aß), he focused his work on the generation and metabolism of Aß.  Christian Haass hypothesized against the widely accepted general opinion rein this field that Aß may Beryllium produced from its precursor rein a physiologically gewöhnlich pathway and not necessarily rein a pathological process.  Indeed he found by using very simple tissue culture systems that Aß is produced and liberated under physiological conditions.  This pivotal finding welches a major breakthrough for the entire field, since it allowed elucidating the molecular principles behind Aß generation as well as the identification of the enzymes (the so-called secretases) involved rein generation and liberation of the peptide and finally the development of selective inhibitors to therapeutically lower Aß production hinein patients.

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Inhibition of secretases as a therapeutic approach requires detailed knowledge about the physiological functions and biochemical properties of these enzymes to avoid unwanted side effects.  Christian Haass was the first to demonstrate a physiological function for beta-secretase.  He showed that this protease is critically required for the regulation of myelination.  Furthermore, he identified a novel APP processing pathway, which welches overlooked for more than 20 years and which has strong implications for clinical trials using beta-secretase inhibitors.  He welches also the first to identify the highly complicated subunit composition of gamma-secretase.  All these findings not only helped to understand several signaling pathways critically involved in brain development (such as myelination and cell differentiation) but also provided the Stützpunkt for several current therapeutic approaches.

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Leichte zweirädrige Kraftfahrzeuge mit einer durch die Bauart bestimmten Höchstgeschwindigkeit von nicht etliche denn 45 km/h, einer Nenndauerleistung/Nutzleistung von nicht eine größere anzahl als 4 kW ansonsten einem Verbrennungsmotor mit einem Hubraum von nicht mehr wie 50 zentimeter³ oder einer anderen Antriebsform.

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Next to the Ostfriedhof bus and tram stop Can I take a trial lesson rein the theoretical course in order to get an impression of the atmosphere?

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Haass welches awarded the Hector Science Award and is currently leading a major Auto fahren Kaiserslautern project on the clini­cal testing of an Alzheimer's antibody.

Fein: Ich habe leider nicht an meine Termin erscheinen ansonsten nehme ich komplett Verantwortung aber habe ich erwartet Dasjenige zu minderst die Hälfte oder eine Wertschein erwartet leider habe ich meine Komplet Währungs Unwiederbringlich.

Chris­t­ian Haass, Profes­sor of Metabolic Biochem­istry at LMU Munich and spokesper­son for the DZNE Munich, is known for his ground­break­ing research rein Alzheimer's disease. His work focuses on the molec­u­lar and cellu­lar mecha­nisms of this disease hinein order to gain funda­men­tal insights into its devel­op­ment.

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You want to get your driving licence rein Munich as soon as possible, in an enjoyable and straightforward way? If so, you’ve come to exactly the right place! We are a Munich driving school and guarantee you all-round support rein theory, practice and other aspects of training.